Treatment:
The
prognosis for malignant mesothelioma remains disappointing, although there have
been some modest improvements in prognosis from newer chemotherapies and
multimodality treatments. Treatment of malignant mesothelioma at earlier stages
has a better prognosis, but cures are exceedingly rare. Clinical behavior of
the malignancy is affected by several factors including the continuous
mesothelial surface of the pleural cavity which favors local metastasis via
exfoliated cells, invasion to underlying tissue and other organs within the
pleural cavity, and the extremely long latency period between asbestos exposure
and development of the disease. The histological subtype and the patient's age
and health status also help predict prognosis. The epithelioid histology
responds better to treatment and has a survival advantage over sarcomatoid
histology.
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